Fecha 14 de Septiembre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Manchester United vs Rangers | 0 - 0 | C | Old Trafford |
| Benfica vs Haopel Tel Aviv | 2 - 0 | B | da Luz |
| Werder Bremen vs Totteham Hotspur | 2 - 2 | A | Weserstadion |
| FC Twente vs Inter Milan | 2 - 2 | A | De Grolsch Veste |
| FC Copenhagen vs Rubin Kazan | 1 - 0 | D | Parken Stadion |
| Lyon vs FC Schalke 04 | 1 - 0 | B | State Gerland |
| Barcelona vs Panathinalkos | 5 - 1 | D | Camp Nou |
| Bursaspor vs Valencia | 0 - 5 | C | Bursa Atatürk |
Fecha 15 de Septiembre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| AC Milan vs Auxerre | 2 - 0 | G | Old Trafford |
| Arsenal vs Sporting Braga | 6 - 0 | H | Emirates Stadium |
| Marselle vs Spartak Moscow | 0 -1 | F | State Velodrome |
| Bayer Munchen vs Roma | 2 - 0 | E | Allianz Arena |
| Real Madrid vs Ajax | 2 - 0 | G | Santiago Bernabeu |
| CFR Cluj vs FC Basel | 2 - 1 | E | Dr Constantin |
| MSK Zilina vs Chelsea | 1 - 4 | F | Stadium Pod |
| Shakhtar Donetsk vs Partizan | 1 - 0 | H | Donbass Arena |
Fecha 28 de Septiembre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Sporting Braga vs Shakhtar Donetsk | 0 - 3 | H | Braga Municipal |
| Chelsea vs Marselle | 2 - 0 | F | Stamford Bridge |
| Spartak Moscow vs MSK Zilina | 3 - 0 | F | Luzhniki Stadion |
| Roma vs CFR Cluj | 2 - 1 | E | Olimpico |
| Ajax vs AC Milan | 1 - 1 | G | Amsterdam Arena |
Auxerre vs Real Madrid
| 0 - 1 | G | Abbe-Deschamps |
| FC Basel vs Bayer Munchen | 1 - 2 | E | St. Jakob-Park |
| Partizan vs Arsenal | 1 - 3 | H | Stadion Partizana |
Fecha 29 de Septiembre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Rubin Kazan vs Barcelona | 1 - 1 | D | Central Stadium |
| Totteham Hotspur vs FC Twente | 4 - 1 | A | White Hart Lane |
| Rangers vs Bursaspor | 1 - 0 | C | Ibrox |
| FC Schalke 04 vs Benfica | 2 - 0 | B | Veltins-Arena |
| Valencia vs Manchester United | 0 - 1 | C | Mestalla |
| Haopel Tel Aviv vs Lyon | 1 - 3 | B | Bloomfield Stadium |
| Inter Milan vs Werder Bremen | 4 - 0 | A | Giuseppe Meazza |
| Panathinalkos vs FC Copenhagen | 0 - 2 | D | Olympic Stadium |
Fecha 19 de Octubre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Spartak Moscow vs Chelsea | 0 - 2 | F | Luzhniki Stadion |
| Sporting Braga vs Partizan | 2 - 0 | H | Braga Municipal |
| Arsenal vs Shakhtar Donetsk | 5 - 1 | H | Emirates Stadium |
| Roma vs FC Basel | 1 - 3 | E | Olimpico |
| Ajax vs Auxerre | 2 - 1 | G | Amsterdam Arena |
| Marselle vs MSK Zilina | 1 - 0 | F | Stade Velodrome |
| Bayer Munchen vs CFR Cluj | 3 - 2 | E | Allianz Arena |
| Real Madrid vs AC Milan | 2 - 0 | G | Santiago Bernabeu |
Fecha 20 de Octubre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Manchester United vs Bursaspor | 1 - 0 | C | Old Trafford |
| Rangers vs Valencia | 1 - 1 | C | Ibrox |
| FC Schalke 04 vs Haopel Tel Aviv | 3 - 1 | B | Veltins-Arena |
| FC Twente vs Werder Bremen | 1 - 1 | A | De Grolsch Veste |
| Inter Milan vs Totteham Hotspur | 4 - 3 | A | Giuseppe Meazza |
| Lyon vs Benfica | 2 - 0 | B | Stade Gerland |
| Barcelona vs FC Copenhagen | 2 - 0 | D | Camp Nou |
| Panathinalkos vs Rubin Kazan | 0 - 0 | D | Olympic Stadium |
Fecha 2 de Noviembre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Rubin Kazan vs Panathinalkos | 0 - 0 | D | Central Stadium |
| Totteham Hotspur vs Inter Milan | 3 - 1 | A | White Hart Lane |
| Benfica vs Lyon | 4 - 3 | B | da Luz |
| Werder Bremen vs FC Twente | 0 - 2 | A | Weserstadion |
| Valencia vs Rangers | 3 - 0 | C | Mestalla |
| FC Copenhagen vs Barcelona | 1 - 1 | D | Parken Stadion |
| Haopel Tel Aviv vs FC Schalke 04 | 0 - 0 | B | Bloomfield Stadium |
| Bursaspor vs Manchester United | 0 - 3 | C | Bursa Atatürk |
Fecha 3 de Noviembre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Chelseavs Spartak Moscow | 4 - 1 | F | Stamford Bridge |
| A C Milan vs Real Madrid | 2 - 2 | G | San Siro |
| Auxerre vs Ajax | 2 - 1 | G | Abbe-Deschamps |
| FC Basel vs Roma | 2 - 3 | E | St. Jakob-Park |
| Partizan vs Sporting Braga | 0 - 1 | H | Stadion Partizana |
| CFR Cluj vs Bayer Munchen | 0 - 4 | E | Dr Constantin |
| MSK Zilina vs Marselle | 0 - 7 | F | Stadium Pod |
| Shakhtar Donetsk vs Arsenal | 2 - 1 | H | Donbass Arena |
Fecha 23 de Noviembre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Spartak Moscow vs Marselle | 0 - 3 | F | Luzhniki Stadion |
| Sporting Braga vs Arsenal | 2 - 0 | H | Braga Municipal |
| Chelsea vsMSK Zilina | 2 - 1 | F | Stamford Bridge |
| Roma vs Bayer Munchen | 3 - 2 | E | Olimpico |
| Ajax vs Real Madrid | 0 - 4 | G | Amsterdam Arena |
| Auxerre vs A C Milan | 0 - 2 | G | Abbe-Deschamps |
| FC Basel vs CFR Cluj | 1 - 0 | E | St. Jakob-Park |
| Partizan vs Shakhtar Donetsk | 0 - 3 | H | Stadion Partizana |
Fecha 24 de Noviembre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Rubin Kazan vs FC Copenhagen | 1 - 0 | D | Central Stadium |
| Totteham Hotspur vs Werder Bremen | 3 - 0 | A | White Hart Lane |
| Rangers vs Manchester United | 0 - 1 | C | Ibrox |
| FC Schalke 04 vs Lyon | 3 - 0 | B | Veltins-Arena |
| Valencia vs Bursaspor | 6 - 1 | C | Mestalla |
| Inter Milan vs FC Twente | 1 - 0 | A | Giuseppe Meazza |
| Haopel Tel Aviv vs Benfica | 3 - 0 | B | Bloomfield Stadium |
| Panathinalkos vs Barcelona | 0 - 3 | D | Olympic Stadium |
Fecha 7 de Diciembre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Manchester United vs Valencia | 1 - 1 | C | Old Trafford |
| Benfica vs FC Schalke 04 | 1 - 2 | B | da Luz |
| Werder Bremen vs Inter Milan | 3 - 0 | A | Weserstadion |
| FC Twente vs Totteham Hotspur | 3 - 3 | A | De Grolsch Veste |
| FC Copenhagen vs Panathinalkos | 3 - 1 | D | Parken Stadion |
| Lyon vs Haopel Tel Aviv | 2 - 2 | B | Stade Gerland |
| Barcelona vs Rubin Kazan | 2 - 0 | B | Camp Nou |
| Bursaspor vs Rangers | 1 - 1 | C | Bursa Atatürk |
Fecha 8 de Diciembre
| **Encuentro** | **Resultado** | **Grupo** | **Estadio** |
| Arsenal vs Partizan | 3 - 1 | H | Emirates Stadium |
| A C Milan vs Ajax | 0 - 2 | G | San Siro |
| Marselle vs Chelsea | 1 - 0 | F | Stade Velodrome |
| Bayer Munchen vs FC Basel | 3 - 0 | E | Allianz Arena |
| Real Madrid vs Auxerre | 4 - 0 | G | Santiago Bernabeu |
| CFR Cluj vs Roma | 1 - 1 | E | Dr. C Rădulescu Stadium |
| MSK Zilina vs Spartak Moscow | 1 - 2 | F | Stadium Pod Dubňom |
| Shakhtar Donetsk vs Sporting Braga | 2 - 0 | H | Donbass Arena |